13774214275
13774214275
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產品型號：S0B1101
更新時間：2025-10-10
廠商性質：生產廠家
訪問量：179
服務熱線15855403091
CTLA-4 （Cytotoxic T-Lymphocyte-Associated Protein 4）, also known as CD152, is a transmembrane protein expressed on the surface of activated T cells. It plays a role in the negative regulation of the immune response and is one of the key targets in immune checkpoint therapy. CTLA-4 shares the same ligands, B7 molecules （including CD80 and CD86）, with CD28; however, unlike CD28, the binding of CTLA-4 to B7 molecules inhibits T cell activation. This inhibitory effect helps prevent excessive immune responses, but in the tumor microenvironment, tumor cells may exploit CTLA-4 to evade immune surveillance and attack.
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