Macrophage-Colony Stimulating Factor （M-CSF）,
also known as Colony Stimulating Factor-1 （CSF-1）, is a hematopoietic growth
factor. It can stimulate the survival, proliferation and differentiation of
mononuclear phagocytes, in addition to the spreading and motility of
macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts,
and endothelial cells. M-CSF interaction with its receptor, c-fms, has been
implicated in the growth, invasion, and metastasis of several diseases,
including breast and endometrial cancers.