Rat Anti-Mouse CD133 Antibody (S-R696)

產(chǎn)品型號(hào)：S0B5122

更新時(shí)間：2025-10-08

廠商性質(zhì)：生產(chǎn)廠家

訪問量：62

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抗體/抗原

ELISA試劑盒抗體試劑盒二抗試劑盒二抗其它流式抗體瓊脂糖/磁珠偶聯(lián)抗體抗Payload抗體泛修飾抗體標(biāo)簽/內(nèi)參抗體功能性抗體 Biosimilar抗體偶聯(lián)抗體配對抗體病理/IHC抗體

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產(chǎn)品介紹

CD133, also known as prominin-1, is a pentaspan transmembrane glycoprotein encoded by the PROM1 gene. It is widely recognized as a biomarker for the isolation and identification of stem cells and cancer stem cells （CSCs） in various tissues and cancers. This 97-kDa protein features five transmembrane domains, with its N-terminus extending into the extracellular space and the C-terminus residing intracellularly. CD133 is predominantly expressed in cellular protrusions and has been associated with tumorigenesis, metastasis, chemotherapy resistance, and poor prognosis in several cancers, including colorectal, liver, and breast cancer. Additionally, CD133+ cells have demonstrated angiogenic potential and may play a role in tumor vascularization. Recent studies also suggest that CD133 could serve as a predictive marker for anti-angiogenic therapies, such as bevacizumab treatment in metastatic colorectal cancer.

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